| Ceftizoxime Basic information | |
| Product Name: | Ceftizoxime |
| Synonyms: | (6 r, 7 r) – 7 – [(Z) -, 2 – (2 – Amino – 4 – thiazolyl) – 2 – methoxyiminoacetylamino] – 8 – oxo – 5 – thia – 1 – azabicyclo [4.2.0] oct – 2 – ene – 2 – carboxylic acid; Ceftizox; (7R)-7-[[2-(2-Aminothiazole-4-yl)-2-(methoxyimino)-1-oxoethyl]amino]cepham-3-ene-4-carboxylicacid; Ceftizoxime (350 mg) I0E2620. 999 mg/mg (an) |
| CAS: | 68401-81-0 |
| MF: | C13H13N5O5S2 |
| MW: | 383.4 |
| EINECS: | 629-729-8 |
| Product Categories: | Thiazole; β-lactam antibiotics; Antibiotics; Drugs; Pharmaceutical intermediate; Chemical impurity – cefazoxime; Pharmaceutical raw materials; Chemical reagent |
| Introduction | Cefazoxime is a third generation cephalosporin, which has broad spectrum antibacterial effect and antibacterial spectrum is similar to cefotaxime. Stable against a broad spectrum of β-lactamases (including penicillinase and cephalosporin enzyme) produced by a variety of Gram-positive and Gram-negative bacteria.
Cefazoxime is a white or light yellow crystal under normal conditions. |
| Application | The third generation cephalosporin antibiotics have antibacterial effect on a variety of Gram-positive and negative bacteria, but the effect on Gram-negative bacteria is stronger. It is used FOR RESPIRATORY SYSTEM INFECTION, urinary system infection, biliary tract infection, bone and joint infection, skin and soft tissue infection, gynecological diseases, septicemia, peritonitis, meningitis and endocarditis caused by sensitive bacteria. |
| Ceftizoxime Chemical Properties | |
| Melting point | 227° (dec) |
| Density | 1.89±0.1 g/cm3(Predicted) |
| Storage condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Solubility | Aqueous Base (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated, So |
| form | Powder. |
| color | White to Pale Yellow |
| pKa | pKa 2.1 (Uncertain) |
